ICSI (Intracytoplasmic Sperm Injection)

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ICSI (Intracytoplasmic Sperm Injection)

ICSI is a very effective method to fertilize eggs in the IVF lab after they have been aspirated from the female. Its main use is for significant male infertility cases

Indications for ICSI

  1. Severe male factor infertility that do not want donor sperm insemination.
  2. Couples with infertility with:
    • o Sperm concentrations of less than 15-20 million per milliliter
      o Low sperm motility – less than 35%
      o Very poor sperm morphology (subjective – specific cutoff value is debatable)
  3. Having previous IVF with no fertilization – or a low rate of fertilization (low percentage of mature eggs that were normally fertilized)
  4. Sometimes it is used for couples that have a low yield of eggs at egg retrieval. In this scenario, ICSI is being used to try to get a higher percentage of eggs fertilized than with conventional insemination of the eggs (mixing eggs and sperm together).

What are the advantages of ICSI?

  • ICSI may give you and your spouse a chance of conceiving your genetic child when other options are closed to you.
  • If your spouse is too anxious to ejaculate on the day of egg collection for standard IVF, sperm can instead be extracted for ICSI.
  • ICSI can also be used to help couples with unexplained infertility, though experts haven’t found that ICSI makes pregnancy any more likely than standard IVF.
  • ICSI doesn’t appear to affect how children conceived via the procedure developmentally or physically.
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